Sperm tsRNAs and acquired metabolic disorders

Sperm tsRNAs and acquired metabolic disorders.

Many findings support the hypothesis that metabolic changes associated with environmental factors can be transmitted from father to offspring. The molecular mechanisms underlying the intergenerational transmission of metabolic changes remain to be fully explored. These acquired metabolic disorders in offspring may be partially explained by some potential epigenetic information carriers such as ...

Sperm tsRNAs contribute to intergenerational inheritance of an acquired metabolic disorder.

Increasing evidence indicates that metabolic disorders in offspring can result from the father's diet, but the mechanism remains unclear. In a paternal mouse model given a high-fat diet (HFD), we showed that a subset of sperm transfer RNA-derived small RNAs (tsRNAs), mainly from 5' transfer RNA halves and ranging in size from 30 to 34 nucleotides, exhibited changes in expression profiles and RN...

irisin and metabolic disorders

Endocrine and metabolic disorders in &#946 -thalassemia major patients

Background: Thalassemia is the most common hereditary anemia and beta thalassemia major is its most severe form. Endocrine abnormalities in thalassemia major are common disturbing complications that need prompt management. The purpose of this study was to determine the endocrine disorders and bone mineral density in patients with major -thalassemia in Qazvin, Iran. Methods: In this cross- sect...

The Relationship between Metabolic Disorders and Helminth Diseases

Les auteurs passent en revu les perturbations du metabolisme general et particulier et en tirent les consequences d'ordre pathologique et therapeutique.